Soleno Therapeutics Announces Collaboration with Vanderbilt University to Discover and Develop Next Generation K(ATP) Channel Activators for the Treatment of Rare Diseases
ATP-dependent potassium (or KATP) channels are present in several tissues in the body. Activating these channels has been shown to be beneficial in the treatment of various rare diseases, such as hyperinsulinemic hypoglycemia. Soleno’s product candidate, DCCR, is a potent activator of KATP channels and has demonstrated significant benefits in a Phase 3 study for the treatment of Prader-Willi syndrome (PWS).
“The insight we already have serves as an effective foundation to identify, characterize and develop novel KATP channel activators that may be more potent, specific and/or safer than currently approved therapeutics,” said
“Having discovered the only new KATP channel activator chemistries in the last 20 years, the highly experienced team of Drs. Lindsley and Denton are ideally suited to work with us to identify and characterize novel drug candidates that could serve as the underpinnings for our next generation of products,” said
The initial aims of this collaboration are to develop robust in vivo and in vitro tools to identify and characterize novel KATP channel activators from recently identified new classes of chemistry. Soleno expects to advance appropriate candidates generated from this collaboration into the clinic in the future.
About Soleno Therapeutics, Inc.
Soleno is focused on the development and commercialization of novel therapeutics for the treatment of rare diseases. The company’s lead candidate DCCR (diazoxide choline tablets, a once-daily oral tablet for the treatment of Prader-Willi Syndrome (PWS), is currently being evaluated in a Phase 3 clinical development program. Diazoxide choline has received Orphan Drug Designation for the treatment of PWS in the U.S. and EU, and Fast Track Designation in the U.S. For more information, please visit www.soleno.life.
This press release contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended. All statements other than statements of historical facts contained in this press release are forward-looking statements, including statements regarding the potential of KATP channel activators for the treatment of hyperphagic obesity syndromes. In some cases, you can identify forward-looking statements by terms such as "may," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "contemplates," "believes," "estimates," "predicts," "potential" or "continue" or the negative of these terms or other similar expressions. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions, including the risks and uncertainties associated with market conditions, as well as risks and uncertainties inherent in Soleno’s business, including those described in the company's prior press releases and in the periodic reports it files with the SEC. The events and circumstances reflected in the company's forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward-looking statements. Except as required by applicable law, the company does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.
Source: Soleno Therapeutics