Entity Central Index Key
Finite lived intangible assets amortization expense after year four.
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
Entity Current Reporting Status
Entity Current Reporting Status
Entity Voluntary Filers
Entity Voluntary Filers
Entity Interactive Data Current
Entity Interactive Data Current
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Shell Company
Entity Shell Company
Entity Emerging Growth Company
Entity Emerging Growth Company
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Entity File Number
Entity File Number
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Public Float
Entity Public Float
Auditor Name
Auditor Name
Auditor Location
Auditor Location
Auditor Firm ID
Auditor Firm Id
Title of 12(b) Security
Security12b Title
Trading Symbol
Trading Symbol
Security Exchange Name
Security Exchange Name
Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to clinical trial services received from vendors, such as accrued contract research organization costs, patient costs, clinical site costs and clinical product cost. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Statement Of Financial Position [Abstract]
Statement [Table]
Statement [Table]
Class of Warrant or Right
Class Of Warrant Or Right [Axis]
Class of Warrant or Right
Class Of Warrant Or Right [Domain]
2018 PIPE warrant liability.
2018 PIPE Warrant Liability [Member]
Two Thousand Eighteen P I P E Warrant Liability [Member]
Statement [Line Items]
Statement [Line Items]
Assets
Assets [Abstract]
Current assets
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Long-term assets
Assets Noncurrent [Abstract]
Property and equipment, net
Property Plant And Equipment Net
Operating lease right-of-use assets
Operating Lease Right Of Use Asset
Finance lease right-of-use assets
Finance Lease Right Of Use Asset
Intangible assets, net
Intangible Assets Net Excluding Goodwill
Other long-term assets
Other Assets Noncurrent
Total assets
Assets
Liabilities and stockholders’ equity
Liabilities And Stockholders Equity [Abstract]
Current liabilities
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued compensation
Employee Related Liabilities Current
Accrued clinical trial site costs
Accrued Clinical Trial Costs Current
Operating lease liabilities
Operating Lease Liability Current
Other current liabilities
Other Liabilities Current
Total current liabilities
Liabilities Current
Long-term liabilities
Liabilities Noncurrent [Abstract]
Warrant liability
Derivative Liabilities Noncurrent
Contingent liability for Essentialis purchase price
Asset Acquisition Contingent Consideration Liability Noncurrent
Long-term lease liabilities
Operating Lease Liability Noncurrent
Total liabilities
Liabilities
Commitments and contingencies (Note 8)
Commitments And Contingencies
Stockholders’ equity
Stockholders Equity [Abstract]
Common stock, $0.001 par value, 250,000,000 shares authorized, 79,864,310 and 79,615,692 shares issued and outstanding at December 31, 2021 and December 31, 2020, respectively.
Common Stock Value
Additional paid-in-capital
Additional Paid In Capital Common Stock
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders’ equity
Stockholders Equity
Total liabilities and stockholders’ equity
Liabilities And Stockholders Equity
Common stock, par value (in dollars per share)
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares issued
Common Stock Shares Issued
Common stock, shares outstanding
Common Stock Shares Outstanding
Asset acquisition contingent consideration change in fair value.
Income Statement [Abstract]
Operating expenses
Operating Expenses [Abstract]
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Change in fair value of contingent consideration
Asset Acquisition Contingent Consideration Change In Fair Value
Total operating expenses
Operating Expenses
Operating loss
Operating Income Loss
Other income
Nonoperating Income Expense [Abstract]
Change in fair value of warrants liabilities
Fair Value Adjustment Of Warrants
Interest income
Other Nonoperating Income Expense
Total other income
Nonoperating Income Expense
Net loss
Net Income Loss
Loss per common share, basic and diluted
Earnings Per Share Basic And Diluted
Weighted-average common shares outstanding used to calculate basic and diluted net loss per common share
Weighted Average Number Of Share Outstanding Basic And Diluted
Issuance of restricted stock units shares and option exercises under equity incentive plan.
Issuance of restricted stock units value and option exercises under equity incentive plan.
Issuance of restricted stock units shares under equity incentive plan.
Issuance of restricted stock units value under equity incentive plan,
Statement Of Stockholders Equity [Abstract]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional Paid-In Capital [Member]
Additional Paid In Capital [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Balances at beginning
Balances at beginning (shares)
Shares Outstanding
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase Decrease In Stockholders Equity Roll Forward
Stock-based compensation
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Issuance of restricted stock units under equity incentive plan
Issuance Of Restricted Stock Units Value Under Equity Incentive Plan
Issuance of restricted stock units shares under equity incentive plan, net of tax withholdings.
Issuance of restricted stock units under equity incentive plan, net of tax withholdings (shares)
Issuance Of Restricted Stock Units Shares Under Equity Incentive Plan Net Of Tax Withholdings
Issuance of restricted stock units and option exercises under equity incentive plan
Issuance Of Restricted Stock Units Value And Option Exercises Under Equity Incentive Plan
Issuance of restricted stock units and option exercises under equity incentive plan (shares)
Issuance Of Restricted Stock Units Shares And Option Exercises Under Equity Incentive Plan
Issuance of common stock
Stock Issued During Period Value New Issues
Issuance of common stock (shares)
Stock Issued During Period Shares New Issues
Issuance of restricted stock units under equity incentive plan (shares)
Issuance Of Restricted Stock Units Shares Under Equity Incentive Plan
Tax withholding payments for net share-settled equity awards
Adjustments To Additional Paid In Capital Income Tax Deficiency From Share Based Compensation
Tax withholding payments for net share-settled equity awards (shares)
Shares Paid For Tax Withholding For Share Based Compensation
Net loss
Balances at ending
Balances at end (shares)
Less transaction costs
Adjustments To Additional Paid In Capital Stock Issued Issuance Costs
Noncash lease expense.
Increase decrease in accrued clinical trial site costs.
Increase decrease in operating lease liabilities.
Proceeds from sale of common stock and common stock warrants, net of costs.
Statement Of Cash Flows [Abstract]
Cash flows from operating activities:
Net Cash Provided By Used In Operating Activities [Abstract]
Net loss
Profit Loss
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Depreciation and amortization
Depreciation And Amortization
Noncash lease expense
Noncash Lease Expense
Stock-based compensation expense
Share Based Compensation
Change in fair value of stock warrants
Change in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Prepaid expenses, other current assets and other assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Accounts payable
Increase Decrease In Accounts Payable
Accrued compensation
Increase Decrease In Employee Related Liabilities
Accrued clinical trial site costs
Increase Decrease In Accrued Clinical Trial Site Costs
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Other liabilities
Increase Decrease In Other Operating Liabilities
Net cash used in operating activities
Net Cash Provided By Used In Operating Activities
Cash flows from investing activities:
Net Cash Provided By Used In Investing Activities [Abstract]
Purchases of property and equipment
Payments To Acquire Property Plant And Equipment
Net cash used in investing activities
Net Cash Provided By Used In Investing Activities
Cash flows from financing activities:
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from sale of common stock and common stock warrants, net of costs
Proceeds From Sale Of Common Stock And Common Stock Warrants Net Of Costs
Tax withholding payments for net share-settled equity awards
Payments Related To Tax Withholding For Share Based Compensation
Proceeds from stock option exercises
Proceeds From Stock Options Exercised
Principal paid on finance lease liabilities
Finance Lease Principal Payments
Net cash (used in) provided by financing activities
Net Cash Provided By Used In Financing Activities
Net (decrease) increase in cash and cash equivalents
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Cash and cash equivalents, beginning of period
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Cash and cash equivalents, end of period
Supplemental disclosure of non-cash investing and financing information
Noncash Investing And Financing Items [Abstract]
Right-of use assets obtained in exchange for operating lease obligations
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
Purchases of property and equipment in accounts payable
Capital Expenditures Incurred But Not Yet Paid
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Accounting Policies [Abstract]
Overview
Business Description And Basis Of Presentation [Text Block]
Going concern and management’s plans.
Cash And Cash Equivalents [Abstract]
Going Concern and Management's Plans
Going Concern And Managements Plans [Text Block]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Fair Value Disclosures [Abstract]
Fair Value of Financial Instruments
Fair Value Disclosures [Text Block]
Other financial statement details disclosure.
Other financial statement details disclosure.
Other Financial Statement Details Disclosure [Abstract]
Other Financial Statement Details
Other Financial Statement Details Disclosure [Text Block]
Warrant Liability Disclosure [Text Block]
Text Block [Abstract]
Warrant Liabilities
Warrant Liability Disclosure [Text Block]
Lessee operating and finance leases.
Leases [Abstract]
Leases
Lessee Operating And Finance Leases [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Equity [Abstract]
Stockholders' Equity
Shareholders Equity And Share Based Payments [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Earnings Per Share [Abstract]
Net loss per share
Earnings Per Share [Text Block]
Compensation And Retirement Disclosure [Abstract]
Defined Contribution Plan
Pension And Other Postretirement Benefits Disclosure [Text Block]
Subsequent Events [Abstract]
Subsequent Events
Subsequent Events [Text Block]
Basis of Presentation
Basis Of Accounting Policy Policy [Text Block]
Use of Estimates
Use Of Estimates
Concentration of Credit Risk
Concentration Risk Credit Risk
Segments
Segment Reporting Policy Policy [Text Block]
Cash and Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Prepaid Expenses And Other Current Assets Policy [Text Block]
Prepaid Expenses and Other Current Assets
Prepaid Expenses And Other Current Assets Policy [Text Block]
Property and Equipment, Net
Property Plant And Equipment Policy [Text Block]
Leases
Lessee Leases Policy [Text Block]
Long-Lived Assets
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Intangible Assets
Intangible Assets Finite Lived Policy
Research and Development
Research And Development Expense Policy
Change in fair value of contingent consideration policy.
Change in Fair Value of Contingent Consideration
Change In Fair Value Of Contingent Consideration Policy [Text Block]
Income Taxes
Income Tax Policy [Text Block]
Common Stock Purchase Warrants and Other Derivative Financial Instruments
Derivatives Policy [Text Block]
Stock-Based Compensation
Share Based Compensation Option And Incentive Plans Policy
Recent Accounting Standards
New Accounting Pronouncements Policy Policy [Text Block]
Summary of Financial Instruments Measured at Fair Value on Recurring Basis
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Table [Text Block]
Summary of Changes in Fair Value of Level 3 Financial Instruments
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Text Block]
Schedule of Property and Equipment
Property Plant And Equipment [Text Block]
Schedule of Intangible Assets
Schedule Of Intangible Assets And Goodwill Table [Text Block]
Schedule of Future Amortization Expense
Scheduleof Finite Lived Intangible Assets Future Amortization Expense Table [Text Block]
Fair Value of Convertible Preferred Stock Warrant Liability
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques Table [Text Block]
Schedule of Components of Lease Expense
Lease Cost Table [Text Block]
Schedule of supplemental cash flow information related to leases.
Schedule Of Supplemental Cash Flow Information Related To Leases
Schedule Of Supplemental Cash Flow Information Related To Leases Table [Text Block]
Operating Lease Liability Maturity
Lessee Operating Lease Liability Maturity Table [Text Block]
Summary of Stock Based Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Schedule of Fair Value of Award Granted Using Black-Scholes Option Pricing Model
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Summary of Stock Option and Restricted Stock Unit Transactions
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Summary of Restricted Stock Unit Transactions
Schedule Of Share Based Compensation Restricted Stock Units Award Activity Table [Text Block]
Schedule of Geographical Distribution of Loss before Income Taxes
Schedule Of Income Before Income Tax Domestic And Foreign Table [Text Block]
Provision for Income Tax Benefit by Applying Statutory Federal Income Tax Rate to Operating Loss
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Significant Components of Company's Deferred Tax Assets and Liabilities
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Summary of Gross Unrecognized Tax Benefits
Schedule Of Unrecognized Tax Benefits Roll Forward Table [Text Block]
Schedule of Potentially Dilutive Securities Outstanding Excluded from Computations of Diluted Weighted-Average Shares Outstanding
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Schedule Of Cash And Cash Equivalents [Table]
Schedule Of Cash And Cash Equivalents [Table]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Underwritten public offering.
Underwritten Public Offering [Member]
Underwritten Public Offering [Member]
Cash And Cash Equivalents [Line Items]
Cash And Cash Equivalents [Line Items]
Net loss
Accumulated deficit
Net cash used in operating activities
Proceeds from sale of common stock, net of costs
Proceeds From Issuance Of Common Stock
Concentration Risk, Credit Risk, Number of Banks
Schedule Of Significant Accounting Policies [Line Items]
Schedule Of Significant Accounting Policies [Table]
Schedule Of Significant Accounting Policies [Table]
Schedule Of Significant Accounting Policies [Table]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Minimum [Member]
Minimum [Member]
Maximum [Member]
Maximum [Member]
Asset purchase.
Asset Purchase
Asset Purchase [Axis]
Asset purchase.
Asset Purchase
Asset Purchase [Domain]
Essentialis, Inc.
Essentialis, Inc. [Member]
Essentialis Inc [Member]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Stock Options [Member]
Employee Stock Option [Member]
Accounting Standards Update
Adjustments For New Accounting Pronouncements [Axis]
Accounting Standards Update
Type Of Adoption [Member]
ASU 2019-12 [Member]
Accounting Standards Update201912 [Member]
Schedule Of Significant Accounting Policies [Line Items]
Schedule Of Significant Accounting Policies [Line Items]
Number of commercial banks
Concentration Risk Credit Risk Numberof Banks
Number of operating segments
Number Of Operating Segments
Estimated useful lives of property and equipment
Property Plant And Equipment Useful Life
Net intangible assets acquired
Business Combination Recognized Identifiable Assets Acquired And Liabilities Assumed Intangible Assets Other Than Goodwill
Estimated useful life
Finite Lived Intangible Asset Useful Life
Expected dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Change in accounting principle, accounting standards update, adopted
Change In Accounting Principle Accounting Standards Update Adopted
Change in accounting principle, accounting standards update, adoption date
Change In Accounting Principle Accounting Standards Update Adoption Date
Change in accounting principle, accounting standards update, immaterial effect
Change In Accounting Principle Accounting Standards Update Immaterial Effect
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Level 1 [Member]
Fair Value Inputs Level1 [Member]
Level 2 [Member]
Fair Value Inputs Level2 [Member]
Level 3 [Member]
Fair Value Inputs Level3 [Member]
Measurement Frequency
Fair Value By Measurement Frequency [Axis]
Measurement Frequency
Fair Value Measurement Frequency [Domain]
Fair Value, Measurements, Recurring [Member]
Fair Value Measurements Recurring [Member]
Liability Class
Fair Value By Liability Class [Axis]
Fair Value by Liability Class
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation By Liability Class [Domain]
Derivative Financial Instruments, Liabilities
Derivative Financial Instruments Liabilities [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Liabilities
Liabilities Fair Value Disclosure [Abstract]
Total common stock warrant and contingent consideration liability
Liabilities Fair Value Disclosure
Asset acquisition contingent consideration arrangements earn out payment,
Percentage of the probability of achieving the milestone.
Commercial milestones in applicable revenue, year four.
Commercial milestones in applicable revenue, year three.
Maximum potential cash earnout payments
Asset Acquisition Contingent Consideration Arrangements Earn Out Payment
Percentage of probability of achieving milestone
Percentage Of Probability Of Achieving Milestone
Commercial milestones in applicable revenue, 2024
Commercial Milestones In Applicable Revenue Year Three
Commercial milestones in applicable revenue, 2025
Commercial Milestones In Applicable Revenue Year Four
Expiration of warrants.
Fair value measurement with unobservable inputs reconciliation recurring basis liability expiration.
Fair value measurement with unobservable inputs reconciliation recurring basis change in liability due to estimated future revenue milestones.
Fair value measurement with unobservable inputs reconciliation recurring basis change in liability due to assignment of rights.
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Series C Warrants [Member]
Series C Warrant [Member]
Series C Warrants [Member]
2017 PIPE warrant liability.
2017 PIPE Warrant Liability [Member]
Two Thousand Seventeen P I P E Warrant Liability [Member]
Common Stock Warrant Liability [Member]
Common stock warrant liability [Member]
Common Stock Warrant Liability [Member]
Common stock warrant liability [Member]
Purchase price contingent liability.
Purchase price contingent liability [Member]
Purchase Price Contingent Liability [Member]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation Calculation Roll Forward
Balance at the beginning of period
Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Value
Balance at the beginning of period, in shares
Class Of Warrant Or Right Outstanding
Change in value of liabilities
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Gain Loss Included In Earnings
Expiration of warrants, in shares
Expiration Of Warrants
Expiration of warrants
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Liability Expiration
Change in value of contingent liability due to estimated future revenue milestones
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Change In Liability Due To Estimated Future Revenue Milestones
Change in value of contingent liability due to assignment of rights to Soleno
Fair Value Measurement With Unobservable Inputs Reconciliation Recurring Basis Change In Liability Due To Assignment Of Rights
Balance at end of period
Balance at the end of period, in shares
Property, Plant and Equipment [Line Items]
Schedule Of Property Plant And Equipment [Table]
Long-Lived Tangible Asset
Property Plant And Equipment By Type [Axis]
Long-Lived Tangible Asset
Property Plant And Equipment Type [Domain]
Computer Hardware [Member]
Computer Equipment [Member]
Furniture and Fixtures [Member]
Furniture And Fixtures [Member]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Property and equipment, gross
Property Plant And Equipment Gross
Less accumulated depreciation and amortization
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Total
Depreciation expense
Depreciation
Schedule Of Finite Lived Intangible Assets [Table]
Schedule Of Finite Lived Intangible Assets [Table]
Finite-Lived Intangible Assets by Major Class
Finite Lived Intangible Assets By Major Class [Axis]
Finite-Lived Intangible Assets, Major Class Name
Finite Lived Intangible Assets Major Class Name [Domain]
Patents and Merger Costs [Member]
Patents and Merger Costs [Member]
Patents And Merger Costs [Member]
Finite Lived Intangible Assets [Line Items]
Finite Lived Intangible Assets [Line Items]
Amount
Finite Lived Intangible Assets Gross
Accumulated Amortization
Finite Lived Intangible Assets Accumulated Amortization
Net Amount
Finite Lived Intangible Assets Net
Patents And Trademark [Member]
Patents And Trademark [Member]
Patents And Trademark [Member]
2022
Finite Lived Intangible Assets Amortization Expense Next Twelve Months
2023
Finite Lived Intangible Assets Amortization Expense Year Two
2024
Finite Lived Intangible Assets Amortization Expense Year Three
2025
Finite Lived Intangible Assets Amortization Expense Year Four
2026 and thereafter
Finite Lived Intangible Assets Amortization Expense After Year Four
Amortization
Adjustment For Amortization
Tender offer expiration date.
Warrants exercised prior to expiration.
Class Of Warrant Or Right [Table]
Class Of Warrant Or Right [Table]
Two thousand eighteen PIPE warrant liability to purchase common stock.
2018 PIPE Warrant Liability [Member]
Two Thousand Eighteen P I P E Warrant Liability To Purchase Common Stock [Member]
Measurement Input Type
Measurement Input Type [Axis]
Measurement Input Type
Measurement Input Type [Domain]
Expected Dividend Yield [Member]
Measurement Input Expected Dividend Rate [Member]
Class Of Warrant Or Right [Line Items]
Class Of Warrant Or Right [Line Items]
Number of common stock purchased upon issuance of warrants
Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights
Warrants exercised prior to expiration
Warrants Exercised Prior To Expiration
Tender offer expiration date
Tender Offer Expiration Date
Class of Warrant or Right, Exercise Price Description
Exercise price of warrants exercised
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Warrant issuance description
Class Of Warrant Or Right Exercise Price Description
Fair value of estimated warrants
Warrants And Rights Outstanding
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Volatility [Member]
Measurement Input Price Volatility [Member]
Contractual Term [Member]
Measurement Input Expected Term [Member]
Risk-free Rate [Member]
Measurement Input Risk Free Interest Rate [Member]
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Line Items]
Measurement input
Warrants And Rights Outstanding Measurement Input
Measurement term
Warrants And Rights Outstanding Term
Lessee, operating lease commencement month and year.
Lessee, operating lease month and year of expiration.
Lessee Lease Description [Table]
Lessee Lease Description [Table]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Redwood City, California [Member]
CALIFORNIA
Lessee Lease Description [Line Items]
Lessee Lease Description [Line Items]
Area of operating lease
Area Of Real Estate Property
Operating lease, description
Lessee Operating Lease Description
Operating lease beginning date
Lessee Operating Lease Commencement Month And Year
Operating lease, expiration
Lessee Operating Lease Month And Year Of Expiration
Payment to acquire office furniture under operating lease
Payments To Acquire Furniture And Fixtures
Current finance lease liabilities
Finance Lease Liability Current
Finance Lease Liability Current Statement Of Financial Position Extensible List
Finance Lease Liability Current Statement Of Financial Position Extensible List
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Operating Lease Liability Noncurrent Statement Of Financial Position Extensible List
Long-term finance lease liabilities
Finance Lease Liability Noncurrent
Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible List]
Finance Lease Liability Noncurrent Statement Of Financial Position Extensible List
Operating lease cost and sublease income.
Finance lease cost.
Operating lease cost
Operating Lease Cost
Variable lease cost
Variable Lease Cost
Short-term lease cost
Short Term Lease Cost
Total operating lease cost
Operating Lease Cost And Sublease Income
Amortization of right-of-use assets
Finance Lease Right Of Use Asset Amortization
Interest on lease liabilities
Finance Lease Interest Expense
Total finance lease cost
Finance Lease Cost
Cash paid for amounts included in measurement of lease liabilities.
Cash paid for amounts included in the measurement of lease liabilities:
Cash Paid For Amounts Included In Measurement Of Lease Liabilities [Abstract]
Operating cash flows from operating leases
Operating Lease Payments
Operating cash flows from finance leases
Finance Lease Interest Payment On Liability
Financing cash flows from finance leases
2022
Lessee Operating Lease Liability Payments Due Next Twelve Months
2023
Lessee Operating Lease Liability Payments Due Year Two
Total lease payments
Lessee Operating Lease Liability Payments Due
Less interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Total
Operating Lease Liability
Finance lease, weighted-average remaining lease term
Finance Lease Weighted Average Remaining Lease Term1
Finance lease, discount rate
Finance Lease Weighted Average Discount Rate Percent
Operating lease, weighted-average remaining lease term
Operating Lease Weighted Average Remaining Lease Term1
Operating lease, discount rate
Operating Lease Weighted Average Discount Rate Percent
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Series D Warrants [Member]
Series D Warrants [Member]
Series D Warrants [Member]
Warrants To Purchase Stock [Member]
Warrants to Purchase Stock [Member]
Warrants To Purchase Common Stock [Member]
Underwriter [Member]
Underwriter [Member]
Underwriter [Member]
Debt Instrument
Debt Instrument [Axis]
Debt Instrument, Name
Debt Instrument Name [Domain]
Two Thousand and Ten and Two Thousand and Twelve Convertible Promissory Notes [Member]
2010 and 2012 Convertible Promissory Notes [Member]
Two Thousand And Ten And Two Thousand And Twelve Convertible Promissory Notes [Member]
Incentive Stock Options [Member]
ISOs [Member]
Incentive Stock Options [Member]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
2014 equity incentive plan.
2014 Equity Incentive Plan [Member]
Two Thousand And Fourteen Equity Incentive Plan [Member]
Two thousand twenty inducement equity incentive plan.
2020 Inducement Equity Incentive Plan [Member]
Two Thousand Twenty Inducement Equity Incentive Plan [Member]
Performance-Based Options [Member]
Performance Shares [Member]
Restricted Stock Units [Member]
Restricted Stock Units R S U [Member]
Employee Stock Purchase Plan [Member]
Employee Stock [Member]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Convertible preferred stock, shares authorized
Preferred Stock Shares Authorized
Number of shares issued upon full exercise of underwriters options to purchase additional shares.
Number of newly issued shares
Shares issued upon exercise of underwriters options
Number Of Shares Issued Upon Full Exercise Of Underwriters Options To Purchase Additional Shares
Price per unit
Shares Issued Price Per Share
Net proceeds from issuance of public offering
Proceeds From Issuance Initial Public Offering
Class of warrants exercised.
Warrants outstanding (in shares)
Warrants expiration date
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Exercise price of warrants (in dollars per share)
Warrants exercised
Class Of Warrants Exercised
Class Of Warrant Or Right, Warrant Term
Class of warrant or right warrants expiration month and year.
Warrants term
Class Of Warrant Or Right Warrant Term
Warrants expiration period
Class Of Warrant Or Right Warrants Expiration Month And Year
Ownership interest, percentage of voting rights of stock.
Ownership interest of voting rights of all classes of stock (percent)
Ownership Interest Percentageof Voting Rightsof Stock
Percentage of fair market value
Sharebased Compensation Arrangement By Sharebased Payment Award Purchase Price Of Common Stock Percent
Vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Contractual term of option
Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period
Number of shares available for grant
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Number of shares reserved for issuance
Common Stock Capital Shares Reserved For Future Issuance
Stock-based compensation expense
Allocated Share Based Compensation Expense
Income tax benefits recognized from stock-based compensation
Employee Service Share Based Compensation Tax Benefit From Compensation Expense
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development [Member]
Research And Development Expense [Member]
General and Administrative [Member]
General And Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense
Number of options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Expected life (years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Risk-free interest rate, Maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Maximum
Volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Volatility, Maximum
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Maximum
Weighted average volatility
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Weighted Average Volatility Rate
Dividend rate
Two thousand and fourteen equity incentive plan and two thousand twenty inducement equity incentive plan.
2014 Plan and Inducement Plan [Member]
Two Thousand And Fourteen Equity Incentive Plan And Two Thousand Twenty Inducement Equity Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Roll Forward
Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Options granted
Options exercised
Stock Issued During Period Shares Stock Options Exercised
Options canceled/forfeited
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period
Ending balance
Options exercisable at end of period (shares)
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Number
Options vested and expected to vest at end of period (shares)
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Weighted Average Grant Date Fair Value [Roll Forward]
Weighted-Average Exercise Price per Share
Sharebased Compensation Arrangementby Sharebased Payment Award Options Nonvested Weighted Average Grant Date Fair Value Roll Forward
Beginning balance (in dollars per share)
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Options granted (in dollars per share)
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Options exercised (in dollars per share)
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Options canceled/forfeited (in dollars per share)
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Ending balance (in dollars per share)
Options exercisable at end of period (in dollars per share)
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Weighted Average Exercise Price
Options vested and expected to vest at end of period (in dollars per share)
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
Weighted Average Remaining Contractual Term
Share Based Compensation Arrangement By Share Based Payment Award Options Additional Disclosures [Abstract]
Options outstanding at end of period
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Options exercisable at end of period
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Exercisable Weighted Average Remaining Contractual Term1
Options vested and expected to vest at end of period
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1
Share based compensation arrangement by share based payment award options non vested aggregate intrinsic value.
Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Non Vested Aggregate Intrinsic Value
Options outstanding at end of period
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Options exercisable at end of period
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Exercisable Aggregate Intrinsic Value
Options vested and expected to vest at end of period
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
Share based compensation arrangement by share based payment award options exercised intrinsic value.
Weighted average grant date fair value per option granted (in dollars per share)
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Future stock-based compensation for unvested employee options granted and outstanding
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Future stock-based compensation, requisite service period
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Stock options exercised, intrinsic value
Share Based Compensation Arrangement By Share Based Payment Award Options Exercised Intrinsic Value
Stock units granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Vesting percentage
Sharebased Compensation Arrangement By Sharebased Payment Award Award Vesting Rights Percentage
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Roll Forward
Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Restricted stock units granted
Restricted stock units vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Restricted stock units cancelled
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period
Ending balance
Weighted-average grant date fair value
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value Roll Forward
Beginning balance (in dollars per share)
Restricted stock units granted (in dollars per share)
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Restricted stock units vested (in dollars per share)
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Restricted stock units cancelled (in dollars per share)
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value
Ending balance (in dollars per share)
Weighted average grant-date fair value of all restricted stock units granted
Percentage of outstanding stock maximum
Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Outstanding Stock Maximum
Number of shares available for issuance under the plan on the first day of each year
United States
Income Loss From Continuing Operations Before Income Taxes Domestic
Foreign
Income Loss From Continuing Operations Before Income Taxes Foreign
Loss before income taxes
Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest
Income tax reconciliation change in fair value of warrants.
Income tax reconciliation change in fair value of contingent consideration.
Income tax reconciliation change in net operating loss.
Income Tax Expense Benefit Continuing Operations Income Tax Reconciliation [Abstract]
Tax (benefit) on the loss before income tax expense computed at the federal statutory rate
Income Tax Reconciliation Income Tax Expense Benefit At Federal Statutory Income Tax Rate
State tax (benefit) at statutory rate, net of federal benefit
Income Tax Reconciliation State And Local Income Taxes
Foreign rate differential
Income Tax Reconciliation Foreign Income Tax Rate Differential
Change in valuation allowance
Income Tax Reconciliation Change In Deferred Tax Assets Valuation Allowance
Change in research and development credits
Income Tax Reconciliation Tax Credits Research
Stock based compensation—ISOs
Income Tax Reconciliation Nondeductible Expense Share Based Compensation Cost
Change in fair value of warrants
Income Tax Reconciliation Change In Fair Value Of Warrants
Change in fair value of contingent consideration
Income Tax Reconciliation Change In Fair Value Of Contingent Consideration
Change in net operating loss true up
Income Tax Reconciliation Change In Net Operating Loss
Other
Income Tax Reconciliation Other Reconciling Items
Provision for income tax benefit
Income Tax Expense Benefit
Deferred tax assets lease liability.
Deferred tax liabilities right-of-use assets.
Components Of Deferred Tax Assets [Abstract]
Non-current deferred tax assets:
Deferred Tax Assets Net Noncurrent Classification [Abstract]
Federal and state net operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Research and other credits
Deferred Tax Assets Tax Credit Carryforwards
Reserves and accruals
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals
Fixed assets
Deferred Tax Assets Property Plant And Equipment
Capital loss carryover
Deferred Tax Assets Capital Loss Carryforwards
Stock based compensation
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Lease liability
Deferred Tax Assets Lease Liability
Other deferred tax assets
Deferred Tax Assets Tax Credit Carryforwards Other
Gross non-current deferred tax assets
Deferred Tax Assets Gross
Intangible assets
Deferred Tax Liabilities Goodwill And Intangible Assets Intangible Assets
Right-of-use assets
Deferred Tax Liabilities Right Of Use Assets
Total non-current deferred tax liabilities
Deferred Income Tax Liabilities
Total deferred tax assets
Deferred Tax Assets Net
Valuation allowance
Deferred Tax Assets Valuation Allowance
Net deferred tax assets
Deferred Tax Assets Liabilities Net
Income Tax Contingency [Table]
Income Tax Contingency [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
U.S. Federal Jurisdiction [Member]
Domestic Country [Member]
State Tax Jurisdiction [Member]
State And Local Jurisdiction [Member]
Foreign Tax Authority [Member]
Foreign Country [Member]
Tax Credit Carryforward
Tax Credit Carryforward [Axis]
Tax Credit Carryforward, Name
Tax Credit Carryforward Name [Domain]
Research Tax Credit Carryforward [Member]
Research [Member]
Income Tax Authority, Name
Income Tax Authority Name [Axis]
Income Tax Authority, Name
Income Tax Authority Name [Domain]
Her Majesty's Revenue and Customs (HMRC) [Member]
Her Majestys Revenue And Customs H M R C [Member]
Internal Revenue Service (IRS) [Member]
Internal Revenue Service I R S [Member]
Income Tax Contingency [Line Items]
Income Tax Contingency [Line Items]
Increase (decrease) in valuation allowance
Valuation Allowance Deferred Tax Asset Change In Amount
Operating loss carryforwards carried forward indefinitely.
Operating loss carryforwards
Operating Loss Carryforwards
Tax credit carryforwards
Tax Credit Carryforward Amount
Operating loss carryforwards, carried forward indefinitely
Operating Loss Carryforwards Carried Forward Indefinitely
Reconciliation Of Unrecognized Tax Benefits Excluding Amounts Pertaining To Examined Tax Returns Roll Forward
Beginning balance
Unrecognized Tax Benefits
Decrease related to prior year tax positions
Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions
Increase related to current year tax positions
Unrecognized Tax Benefits Increases Resulting From Current Period Tax Positions
Ending balance
Unrecognized assets and liabilities related to uncertain tax positions.
Unrecognized assets and liabilities related to uncertain tax positions
Unrecognized Assets And Liabilities Related To Uncertain Tax Positions
Unrecognized Tax Benefits Offset By Valuation Allowance
Unrecognized Tax Benefits that Would Impact Effective Tax Rate
Unrecognized Tax Benefits That Would Impact Effective Tax Rate
Unrecognized tax benefit offset by change in valuation allowance
Unrecognized Tax Benefits Offset By Valuation Allowance
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Warrants Issued to Underwriter to Purchase Common Stock [Member]
2018 PIPE Warrants [Member]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Warrants Issued to 2010/2012 Convertible Note Holders to Purchase Common Stock [Member]
Convertible Debt Securities [Member]
Options to Purchase Common Stock [Member]
Stock Option [Member]
Outstanding Restricted Stock Units [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive securities excluded from computations of diluted weighted-average shares outstanding
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Matching contribution by Company
Defined Contribution Plan Cost Recognized
Public offering price per pre-funded warrant.
Per share exercise price for Pre-funded warrant.
Proceeds from offering after deducting underwriting discount and other estimated offering expenses.
Subsequent Event [Table]
Subsequent Event [Table]
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent Event [Member]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Number of common stock purchased upon issuance of warrants
Public offering price per pre-funded warrant
Public Offering Price Per Pre Funded Warrant
Per share exercise price for pre-funded warrant
Per Share Exercise Price For Pre Funded Warrant
Exercise price of warrants exercised
Proceeds from offering after deducting underwriting discount and other estimated offering expenses
Proceeds From Offering After Deducting Underwriting Discount And Other Estimated Offering Expenses