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Warrants Issued to Underwriter to Purchase Common Stock [Member] Underwriter [Member] Underwriter [Member] Underwriter [Member] Common Stock, Shares, Outstanding, Ending Balance Common Stock, Shares, Outstanding, Beginning Balance Number of shares available for issuance under the plan on the first day of each year Common stock, shares outstanding Common Stock, Shares, Outstanding Risk-free interest rate Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Restricted stock units canceled/forfeited (in dollars per share) Total operating lease cost Operating Lease Cost And Sublease Income Operating lease cost and sublease income. Other non-cash reconciling items Other Non Cash Reconciling Items Other non-cash reconciling items. Summary of Financial Instruments Measured at Fair Value on Recurring Basis Fair Value Measurements, Recurring and Nonrecurring [Table Text Block] Derivative Financial Instruments, Liabilities [Member] Derivative Financial Instruments, Liabilities [Member] Income Statement Location Income Statement Location [Domain] Options granted (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price 2014 Plan and Inducement Plan [Member] Two Thousand And Fourteen Equity Incentive Plan And Two Thousand Twenty Inducement Equity Incentive Plan [Member] Two thousand and fourteen equity incentive plan and two thousand twenty inducement equity incentive plan. Document Type Document Type Warrants and rights exercisable term from following receipt of U.S. Food and drug administration approval. Warrants And Rights Exercisable Term From Following Receipt of U.S. Food and Drug Administration Approval Warrants and rights exercisable term from following receipt of U.S. Food and drug administration approval Fair Value by Liability Class Fair Value by Liability Class [Domain] Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities Document Quarterly Report Document Quarterly Report Counterparty Name Counterparty Name [Domain] Fair value of estimated warrants Warrants and Rights Outstanding Restricted stock units canceled/forfeited Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Reverse Stock Split Reverse Stock Split Policy [Policy Text Block] Reverse stock split. Entity Filer Category Entity Filer Category Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Total Foreign currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax Weighted Average Remaining Term Warrants term Class Of Warrant Or Right Warrant Term Class Of Warrant Or Right, Warrant Term Total other income Nonoperating Income (Expense) 2018 PIPE Warrant Liability [Member] Two Thousand Eighteen P I P E Warrant Liability To Purchase Common Stock [Member] Two thousand eighteen PIPE warrant liability to purchase common stock. Total liabilities Liabilities Total stockholders’ equity Balances at beginning Balances at ending Equity, Attributable to Parent Intangible Assets, Net (Excluding Goodwill), Total Intangible assets, net Intangible Assets, Net (Excluding Goodwill) Net loss Net loss Net Income (Loss) Other income Nonoperating Income (Expense) [Abstract] ISOs [Member] Incentive Stock Options [Member] Incentive Stock Options [Member] Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Overview Business Description and Basis of Presentation [Text Block] Statement of Financial Position [Abstract] Basis of Presentation and Summary of Significant Accounting Policies Basis of Presentation and Significant Accounting Policies [Text Block] Weighted Average Number of Shares Outstanding, Diluted, Total Weighted-average common shares outstanding used to calculate diluted net loss per common share Weighted Average Number of Shares Outstanding, Diluted Weighted-average common shares outstanding used to calculate diluted shares Price per unit Shares Issued, Price Per Share Warrant Liability Disclosure [Text Block] Warrant Liability Disclosure [Text Block] Warrants Operating lease remaining term Operating Lease, Weighted Average Remaining Lease Term Percentage of fair market value Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent Use of Estimates Use of Estimates, Policy [Policy Text Block] Beginning balance (in dollars per share) Ending balance (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Sale and issuance of warrants to purchase common stock Stock and Warrants Issued During Period, Value, Preferred Stock and Warrants Fair Value Disclosures [Abstract] Percentage of outstanding stock maximum Share-Based Compensation Arrangement by Share-Based Payment Award, Percentage of Outstanding Stock Maximum Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Axis] Measurement Frequency Measurement Frequency [Domain] Change in fair value of contingent consideration Asset Acquisition Contingent Consideration Change In Fair Value Asset acquisition contingent consideration change in fair value. Payments to Acquire Property, Plant, and Equipment, Total Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Restricted stock units vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Sale of common stock\pre-funded warrants in public offering, net of costs (shares) Issuance of common stock (shares) Stock Issued During Period, Shares, New Issues Employee-related Liabilities, Current, Total Accrued compensation Employee-related Liabilities, Current Class of Warrant or Right Class of Warrant or Right [Axis]